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Related Experiment Videos

The Androgen Receptor Gene Mutations Database

B Gottlieb1, H Lehvaslaiho, L K Beitel

  • 1Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital, McGill University, 3755 Chemin de la Cote-Ste-Catherine, Montreal, Quebec H3T 1E2, Canada. mc33@musica.mcgill.ca

Nucleic Acids Research
|February 21, 1998
PubMed
Summary
This summary is machine-generated.

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The androgen receptor (AR) gene mutations database has been updated with 37 new mutations, totaling 309 entries. Enhancements include accession numbers, exon 1 polymorphism data, and large gene deletions for improved cancer predisposition research.

Area of Science:

  • Genetics
  • Bioinformatics
  • Oncology

Background:

  • The androgen receptor (AR) gene plays a crucial role in the development and progression of various cancers, particularly prostate and breast cancer.
  • Understanding AR gene mutations and polymorphisms is essential for identifying cancer predispositions and developing targeted therapies.

Purpose of the Study:

  • To describe the updated version of the androgen receptor (AR) gene mutations database.
  • To detail the enhancements made to the database, including new data types and improved accessibility.
  • To discuss the potential relevance of newly added exon 1 polymorphisms as markers for cancer predisposition.

Main Methods:

  • Systematic curation and integration of reported AR gene mutations.
  • Expansion of the database to include accession numbers, exon 1 polyglutamine (polyGln) and polyglycine (polyGly) tract lengths, and large gene deletions.

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  • Establishment of a searchable online database in collaboration with EMBL-European Bioinformatics Institute.

    • Main Results:

    • The database now contains 309 reported AR gene mutations, an increase of 37 from the previous year.
    • New data fields for exon 1 polymorphisms and large gene deletions have been incorporated.
    • A direct link to a completely searchable database is now available.

    Conclusions:

    • The expanded AR gene mutations database provides a comprehensive resource for researchers studying AR gene alterations.
    • The inclusion of exon 1 polymorphisms may offer insights into genetic predisposition to prostate and breast cancer.
    • The database is accessible online and through various file formats for widespread use.