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GPCRDB: an information system for G protein-coupled receptors
1BIOcomputing, EMBL, Heidelberg, Germany.
Nucleic Acids Research
|February 21, 1998
Summary
The GPCRDB is a comprehensive database for G protein-coupled receptors (GPCRs), integrating experimental and computational data. This resource enhances research into GPCRs, vital for medical sciences.
Area of Science:
- Biochemistry
- Bioinformatics
- Pharmacology
Background:
- G protein-coupled receptors (GPCRs) are crucial drug targets.
- GPCR research generates vast amounts of heterogeneous data.
- A centralized, integrated data system is needed for GPCR research.
Purpose of the Study:
- To establish the G protein-coupled receptor database (GPCRDB) system.
- To collect and disseminate diverse GPCR-related data.
- To create a generic, molecular class-specific database for heterogeneous data.
Main Methods:
- Integrated experimental data: sequences, mutant data, ligand binding constants.
- Incorporated computationally derived data: alignments, 3D models, phylogenetic trees.
- Developed 2D visualization tools for data enhancement.
Main Results:
- The GPCRDB system successfully integrates heterogeneous GPCR data.
- Provides access to both primary experimental and derived computational data.
- Enhances the utility of GPCR data through advanced tools.
Conclusions:
- The GPCRDB is a valuable resource for the scientific community.
- Facilitates research in medical sciences due to GPCR importance.
- The database is accessible via the WWW for global research access.