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Related Experiment Videos

The Eukaryotic Promoter Database EPD

R Cavin Périer1, T Junier, P Bucher

  • 1Swiss Institute for Experimental Cancer Research, Ch. des Boveresses 155, 1066-Epalinges s/Lausanne, Switzerland.

Nucleic Acids Research
|February 21, 1998
PubMed
Summary
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The Eukaryotic Promoter Database (EPD) provides curated, non-redundant data on eukaryotic RNA polymerase II promoters. It serves as a valuable resource for comparative sequence analysis and understanding transcription initiation sites.

Area of Science:

  • Genomics
  • Molecular Biology
  • Bioinformatics

Background:

  • The Eukaryotic Promoter Database (EPD) is a curated collection of eukaryotic RNA polymerase II promoters.
  • Promoters are defined by their transcription initiation sites and are crucial for gene regulation.
  • Existing databases may lack comprehensive annotation or focus on specific promoter types.

Purpose of the Study:

  • To present the Eukaryotic Promoter Database (EPD) as a comprehensive, non-redundant resource for eukaryotic POL II promoters.
  • To facilitate comparative sequence analysis of promoters through structured data extraction.
  • To provide accurate, experimentally validated promoter information for biological research.

Main Methods:

  • Compilation of experimentally characterized eukaryotic POL II promoters.

Related Experiment Videos

  • Independent evaluation of primary experimental data from biological literature.
  • Annotation of promoter entries with evidence, cross-references, and bibliographic details.
  • Integration with EMBL sequence data for flanking regions.

    • Main Results:

    • The EPD contains an annotated, non-redundant collection of eukaryotic POL II promoters.
    • Each promoter entry is supported by direct experimental evidence.
    • The database facilitates dynamic extraction of biologically relevant promoter subsets.
    • EPD provides cross-references to other relevant biological databases.

    Conclusions:

    • The Eukaryotic Promoter Database (EPD) is a valuable, curated resource for researchers studying eukaryotic gene regulation.
    • Its structure supports comparative analysis and the identification of promoter elements.
    • EPD enhances the understanding of transcription initiation by providing reliable, annotated promoter data.