Related Experiment Videos
Databases on transcriptional regulation: TRANSFAC, TRRD and COMPEL
T Heinemeyer1, E Wingender, I Reuter
1Gesellschaft für Biotechnologische Forschung mbH, Mascheroder Weg 1, D-38124 Braunschweig, Germany.
Nucleic Acids Research
|February 21, 1998
Summary
TRANSFAC, TRRD, and COMPEL are databases for transcriptional regulation in eukaryotic cells. They offer distinct views on transcription factors, gene hierarchies, and regulatory elements, with updates and WWW access provided.
Area of Science:
- Bioinformatics
- Molecular Biology
- Genomics
Background:
- Databases are crucial for organizing and accessing biological information.
- Understanding transcriptional regulation is fundamental to cell function and development.
Purpose of the Study:
- To describe the databases TRANSFAC, TRRD, and COMPEL, which store information on transcriptional regulation.
- To detail the quantitative and qualitative changes in these databases and their associated programs.
- To provide access points for these valuable biological resources.
Main Methods:
- Data compilation and curation for TRANSFAC, TRRD, and COMPEL.
- Development and maintenance of database structures and associated software.
- Implementation of World Wide Web (WWW) accessibility for the databases.
Main Results:
- TRANSFAC provides data on transcription factors, binding sites, and profiles.
- TRRD offers insights into the regulatory hierarchy of genes.
- COMPEL details the properties of composite regulatory elements.
Conclusions:
- These databases offer complementary perspectives on eukaryotic transcriptional regulation.
- Regular updates and WWW accessibility enhance the utility of these resources for researchers.
- TRANSFAC, TRRD, and COMPEL serve as essential tools for studying gene regulation.