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Nonsteroidal anti-inflammatory drug induced duodenal web
S Kannan1, P S McGreevy, T E Fullerton
1USD School of Medicine, Sioux Falls, USA.
South Dakota Journal of Medicine
|December 24, 1997
Summary
Duodenal webs, though usually congenital, can cause adult intestinal obstruction. Long-term nonsteroidal anti-inflammatory drug (NSAID) use may be an acquired cause, as seen in a patient with gastric outlet obstruction.
Area of Science:
- Gastroenterology
- Surgical Pathology
Background:
- Duodenal webs are congenital anomalies typically presenting in infancy.
- Adult-onset duodenal webs are rare, with uncertain etiology due to delayed presentation.
Observation:
- Gastrointestinal webs in the small intestine and colon are often acquired defects.
- Long-term nonsteroidal anti-inflammatory drug (NSAID) use is a suspected cause of acquired gastrointestinal webs.
Findings:
- A patient with a history of long-term NSAID use presented with gastric outlet obstruction.
- The obstruction was caused by a duodenal web, suggesting an acquired etiology.
Implications:
- This case highlights the potential role of NSAIDs in the development of duodenal webs in adults.
- Understanding acquired causes of duodenal webs is crucial for accurate diagnosis and management in adult patients.