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Bilateral adrenal neuroblastoma
Y Zaizen1, S Suita, K Yamanaka
1Department of Pediatric Surgery, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Summary
Bilateral adrenal neuroblastoma is rare. This study details two cases, highlighting varied N-myc gene copy numbers and supporting diverse biological features in this uncommon childhood cancer.
Area of Science:
- Pediatric Oncology
- Cancer Genomics
Background:
- Neuroblastoma is a common childhood cancer.
- Bilateral adrenal neuroblastoma is an extremely rare presentation.
Observation:
- Two cases of bilateral adrenal neuroblastoma were identified among 125 patients over 35 years.
- Both cases exhibited rosette fibrillary type neuroblastomas histopathologically.
Findings:
- Case 1 showed 14 copies of the N-myc gene with liver metastases.
- Case 2 had no N-myc gene amplification, detected via mass screening.
Implications:
- These findings suggest significant biological heterogeneity within bilateral adrenal neuroblastoma.
- Understanding N-myc gene status is crucial for characterizing this rare tumor subtype.