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Related Experiment Videos

Familial intracranial aneurysms: an autopsy study

W I Schievink1, J E Parisi, D G Piepgras

  • 1Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota, USA.

Neurosurgery
|December 24, 1997
PubMed
Summary

Familial intracranial aneurysms may stem from an underlying arteriopathy affecting the arterial wall. Autopsy findings reveal medial changes in systemic arteries of affected individuals.

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Area of Science:

  • Neurology
  • Pathology
  • Genetics

Background:

  • Familial intracranial aneurysms are more prevalent than previously recognized.
  • Systematic autopsy studies in familial cases are lacking.
  • Understanding the underlying arteriopathy is crucial.

Purpose of the Study:

  • To investigate the nature of the arteriopathy in familial intracranial aneurysms.
  • To review autopsy findings of patients with familial intracranial aneurysms.

Main Methods:

  • Utilized a computerized diagnostic index to identify patients with intracranial aneurysms.
  • Reviewed medical records, radiographic studies, and autopsy findings.
  • Focused on autopsies performed at Mayo Clinic between 1992 and 1994.

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Main Results:

  • Three out of 28 (11%) patients with intracranial aneurysms had familial cases.
  • Microscopic examination showed medial arterial changes (elastic fiber degeneration, increased ground substance) in 2 of 3 familial cases.
  • These changes were absent in sporadic aneurysm cases.

Conclusions:

  • Familial intracranial aneurysms are associated with an underlying arteriopathy.
  • This arteriopathy primarily involves the tunica media.
  • Systemic (extracranial) arteries are commonly affected.