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Polyarteritis nodosa and the antiphospholipid syndrome
B Dasgupta1, M K Almond, A Tanqueray
1Department of Rheumatology, Southend General Hospital, Westcliff-on-Sea, Essex.
British Journal of Rheumatology
|December 24, 1997
Summary
This case study highlights polyarteritis nodosa (PAN) with visceral aneurysms, renal infarction, and hypertension. Combined immunosuppressive therapy and anticoagulation effectively treated the patient, leading to aneurysm regression.
Area of Science:
- Rheumatology
- Vascular Medicine
- Immunology
Background:
- Classical polyarteritis nodosa (PAN) is a systemic vasculitis.
- Antiphospholipid syndrome (APS) is an autoimmune disorder associated with thrombosis and pregnancy complications.
Observation:
- A female patient presented with classical polyarteritis nodosa (PAN) complicated by visceral aneurysms, renal infarction, and hypertension.
- She also exhibited laboratory findings consistent with antiphospholipid syndrome (APS).
- A large iliofemoral thrombosis developed two months into her illness.
Findings:
- The patient showed a positive response to a treatment regimen combining immunosuppressive therapy and anticoagulation.
- Repeat arteriography confirmed the regression of visceral aneurysms following treatment.
- This case underscores the complex interplay between PAN and APS.
Implications:
- The co-occurrence of PAN and APS presents a therapeutic challenge.
- Effective management involves addressing both vasculitis and thrombotic risks.
- Understanding this association is crucial for optimizing patient outcomes.