Some aspects of the effects of PL-10.1.AK-15 on the gastrointestinal tract
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Updated: Oct 31, 2026

Gastrointestinal Motility Monitor (GIMM)
Published on: December 1, 2010
D Erceg1, V N Simicevic, M Kolega
1Pliva Pharmaceutical Company, Biomedical Department, Zagreb, Croatia.
Abstract:
PL-10.1.AK-15 is an active fragment of a naturally occurring protein first isolated from human gastric juice. Among its other protective effects, PL-10.1.AK-15 has demonstrated a protective effect on the gastrointestinal tract. The aim of this study was to investigate the influence of PL-10.1.AK-15 on two functional parameters of gastrointestinal function: gastric acid secretion and gastrointestinal motility. Gastric acid secretion was assessed in male Wistar rats using a modified method of Shay, while gastrointestinal motility was assessed in male NMRI mice by charcoal propulsion. PL-10.1.AK-15 was given in three different doses (3, 10 and 100 micrograms/kg body weight) in accordance with the experimental protocol. The results of these experiments indicate that PL-10.1.AK-15 in the investigated doses had no influence on gastric acid secretion or gastrointestinal motility.
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