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Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
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Markers of systemic and lung inflammation in childhood asthma

M Navratil1, D Plavec, S Dodig

  • 1Srebrnjak Children's Hospital, Reference Center for Clinical Pediatric Allergology of the Ministry of Health and Social Welfare, Zagreb, Croatia.

The Journal of Asthma : Official Journal of the Association for the Care of Asthma
|October 30, 2009
PubMed

Insights

In children with asthma, higher serum high-sensitivity C-reactive protein (hs-CRP) indicates uncontrolled disease. Hs-CRP and lymphocyte counts effectively differentiate asthma control, with hs-CRP inversely correlating with exhaled nitric oxide (F(E)NO).

Area of Science:

  • Pediatric Allergy and Immunology
  • Respiratory Medicine
  • Biomarker Research

Background:

  • Asthma control in children is crucial for long-term health.
  • Identifying reliable biomarkers for asthma control is an ongoing challenge.
  • Inflammation plays a key role in asthma pathophysiology.

Purpose of the Study:

  • To compare inflammatory biomarkers in children with controlled versus uncontrolled asthma.
  • To investigate the relationship between biomarkers and clinical asthma control indices.
  • To assess the diagnostic accuracy of biomarkers for asthma control.

Main Methods:

  • Studied 62 children with asthma (19 controlled, 43 uncontrolled).
  • Measured spirometry, exhaled nitric oxide (F(E)NO), high-sensitivity C-reactive protein (hs-CRP), and white blood cell counts.
  • Utilized discriminant analysis to identify significant factors for asthma control.

Main Results:

  • Serum hs-CRP levels were significantly higher in children with uncontrolled asthma.
  • Hs-CRP and lymphocyte counts were significant discriminators of asthma control with 82.3% accuracy.
  • Hs-CRP showed a significant inverse association with F(E)NO, with lower F(E)NO at higher hs-CRP levels.

Conclusions:

  • Elevated serum hs-CRP is associated with uncontrolled asthma in children.
  • Hs-CRP and F(E)NO may reflect different underlying etiologies for asthma control loss.
  • Further research is needed on the role of peripheral blood biomarkers in pediatric asthma.
Abstract

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