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[Study on the evaluation of total and regional liver function using 99mTc-GSA dynamic SPECT]
H Fujisawa1, A Shinozuka, H Takenaka
1Department of Radiology, Showa University School of Medicine.
Kaku Igaku. the Japanese Journal of Nuclear Medicine
|December 24, 1997
Summary
99mTc-GSA dynamic SPECT imaging offers a simple method to assess liver function. This technique accurately maps regional and total liver function, aiding in predicting outcomes after liver surgery.
Area of Science:
- Nuclear Medicine
- Medical Imaging
- Hepatology
Background:
- Assessing regional and total liver function is crucial for managing liver diseases.
- Current methods may lack precision or simplicity in evaluating liver function.
- Predicting residual liver function after surgery is vital for patient outcomes.
Purpose of the Study:
- To evaluate regional and total liver function using 99mTc-GSA dynamic SPECT.
- To correlate the new liver functional index with established liver function tests.
- To assess the utility of this method in predicting post-hepatectomy liver function.
Main Methods:
- 58 patients with liver disease and 5 healthy volunteers underwent 99mTc-GSA dynamic SPECT.
- Dual-head gamma camera acquired 60 projection datasets over 60 minutes.
- Liver uptake rate (K value) and liver functional index were calculated from time-activity curves.
Main Results:
- The total liver functional index correlated well with liver function tests (HH15, LHL15).
- Significant differences in the index were observed across Child-Pugh liver dysfunction stages.
- The method demonstrated simplicity, operator independence, and provided 3D regional liver function maps.
Conclusions:
- 99mTc-GSA dynamic SPECT provides a simple and reliable method for assessing regional and total liver function.
- This technique shows promise for predicting residual liver function after hepatectomy.
- The generated 3D liver functional index maps offer precise visualization of liver function distribution.