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Sublingual nifedipine in human pregnancy
1Department of Medicine, Sydney University, Royal North Shore Hospital, Sydney, NSW.
Background:
Nifedipine is widely used for acute lowering of blood pressure in obstetric hypertensive emergencies. It has not been approved for this indication or widely assessed.
Aims:
To examine retrospectively the efficacy of nifedipine over a 12 month period in a high risk obstetric service.
Methods:
Chart review of all patients admitted to hospital in the antenatal period with moderate to severe hypertension. Description of their management, usage of nifedipine, and pregnancy outcome.
Results:
Sublingual nifedipine resulted in significant lowering of blood pressure without hypotension. Pregnancy outcome was satisfactory in all patients.
Conclusions:
Sublingual nifedipine was effective, easy to administer, and without serious complications in this retrospective study.