Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hypothyroid Graves' disease

E Lesho1, R E Jones

  • 1Department of Medicine, Madigan Army Medical Center, Tacoma, Wash, USA.

Southern Medical Journal
|December 24, 1997
PubMed
Summary
This summary is machine-generated.

Spontaneous thyroid function reversal between hypothyroidism and hyperthyroidism may be more common than previously believed. Clinical signs like goiter changes and TSH-receptor antibodies indicate this thyroid lability.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Computational Study of the Structure and Transport in Pyrrolidinium-Li-TFSI-Silica Ionogels.

The journal of physical chemistry. B·2021
Same author

Effects of Strain Rate and Temperature on the Mechanical Properties of Simulated Silica Ionogels.

The journal of physical chemistry. B·2021
Same author

Insight into hydrogen production through molecular simulation of an electrode-ionomer electrolyte system.

The Journal of chemical physics·2019
Same author

An atomic-scale evaluation of the fracture toughness of silica glass.

Journal of physics. Condensed matter : an Institute of Physics journal·2018
Same author

Interaction of NaOH solutions with silica surfaces.

Journal of colloid and interface science·2018
Same author

Telomere length heterogeneity in placenta revealed with high-resolution telomere length analysis.

Placenta·2017
Same journal

SMA's 6th Annual Physicians-in-Training Leadership Conference Abstract Presentations.

Southern medical journal·2026
Same journal

Potential Impact of Lower Federal Loan Availability on Medical Education in Appalachia.

Southern medical journal·2026
Same journal

Experiential Mentorship Skills Training: The Effect on Real-Life Mentoring.

Southern medical journal·2026
Same journal

Social Pressure: How Early Social Context Shapes Career Interest in Medicine.

Southern medical journal·2026
Same journal

Comparing Speed and Accuracy of Artificial Intelligence Large Language Models on the Orthopedic In-Training Examination.

Southern medical journal·2026
Same journal

Don't Wait to Talk about Weight: A 2-Hour Interactive Curriculum Improves Medical Student Skills with Weight Management.

Southern medical journal·2026
See all related articles

Area of Science:

  • Endocrinology
  • Thyroidology
  • Immunology

Background:

  • Spontaneous conversion between hypothyroidism and hyperthyroidism is typically considered rare.
  • Understanding the mechanisms and prevalence of thyroid function lability is crucial for accurate diagnosis and management.

Observation:

  • Five patients exhibited at least two cycles of fluctuating thyroid function, ranging from hypothyroxinemia to hyperthyroxinemia.
  • One patient demonstrated four distinct documented shifts in thyroid status over time.

Findings:

  • Hyperthyroid phases were characterized by positive thyroid-stimulating immunoglobulins (TSI), elevated radioactive iodine uptake (RAIU), and undetectable serum thyroid-stimulating hormone (TSH).
  • Hypothyroid phases showed positive thyrotropin-binding inhibitory immunoglobulin (TBII) but negative TSI.

Related Experiment Videos

  • These distinct serological profiles correlate with cyclic shifts in thyroid hormone levels.

    • Implications:

    • The study suggests spontaneous thyroid function reversal might be more frequent than previously assumed.
    • Clinical indicators such as abrupt goiter size changes, exaggerated treatment responses, or the presence of TSH-receptor antibodies may signal this thyroid function lability.
    • Recognizing these features can improve the diagnosis and management of patients with fluctuating thyroid states.