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Related Experiment Videos

Receptive field changes after strokelike cortical ablation: a role for activation dynamics

S J Sober1, J M Stark, D S Yamasaki

  • 1Department of Neurology, University of Wisconsin, William S. Middleton Veterans Hospital, Madison, Wisconsin 53706-1532, USA.

Journal of Neurophysiology
|February 7, 1998
PubMed
Summary

Neural reorganization after stroke aids recovery. A computational model of macaque middle temporal cortex (area MT) revealed that immediate changes in neural dynamics, not just synaptic plasticity, drive early receptive field alterations post-lesion.

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Area of Science:

  • Neuroscience
  • Computational Neuroscience
  • Systems Neuroscience

Background:

  • Stroke-induced neural reorganization is crucial for functional recovery.
  • Two phases of neural reorganization are hypothesized, but their underlying mechanisms remain unclear.
  • Computer models suggest immediate dynamic changes followed by synaptic plasticity.

Purpose of the Study:

  • To investigate the initial phase of altered cortical function after a small lesion in the macaque middle temporal cortex (area MT).
  • To differentiate between dynamic changes and synaptic plasticity in early post-lesion recovery using a combined physiological and computational approach.

Main Methods:

  • Physiological recordings from the middle temporal cortex (area MT) in macaques following an experimentally induced cortical lesion.

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  • Development and application of a neural network computer model to simulate early post-lesion neural activity.
  • Integration of immunohistochemical findings to refine the computational model.

    • Main Results:

    • Observed significant receptive field (RF) changes, including expansion and contraction, within the first few days post-lesion.
    • The computational model initially reproduced RF expansion but required the inclusion of inhibitory interneuron loss to replicate RF contraction.
    • A correlation between increased firing rate and RF size was successfully predicted by the model.

    Conclusions:

    • Immediate changes in neural activation dynamics, independent of anatomical remodeling, can account for substantial receptive field alterations post-lesion.
    • The observed immunohistochemical changes likely represent an immediate extension of the lesion.
    • These dynamic changes are sufficient to explain rapid behavioral recovery following middle temporal cortex lesions.