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Related Experiment Videos

Monkey posterior parietal cortex neurons antidromically activated from superior colliculus

M Paré1, R H Wurtz

  • 1Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. mp@lsr.nei.nih.gov

Journal of Neurophysiology
|February 7, 1998
PubMed
Summary

Neurons in the lateral intraparietal (LIP) area send signals to the superior colliculus (SC) that contain both visual and eye movement information. This research clarifies the functional role of the posterior parietal cortex (PPC) in guiding saccades.

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Area of Science:

  • Neuroscience
  • Systems Neuroscience
  • Cognitive Neuroscience

Background:

  • The posterior parietal cortex (PPC) and superior colliculus (SC) are crucial for sensorimotor transformations.
  • Understanding the precise communication pathways between PPC and SC is essential for elucidating oculomotor control mechanisms.

Purpose of the Study:

  • To investigate the functional properties of neurons projecting from the lateral intraparietal (LIP) area to the intermediate layers of the SC.
  • To differentiate between visual and saccade-related activity in LIP efferent neurons.

Main Methods:

  • Antidromic activation of LIP neurons by stimulating the SC.
  • Recording neuronal discharge during delayed visually guided and memory-guided saccade tasks in non-human primates.
  • Analysis of receptive field properties and temporal discharge patterns.

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Main Results:

  • A majority of identified LIP efferent neurons possess peripheral visual receptive fields with broad spatial tuning.
  • Many LIP efferent neurons show sustained activity during delay periods and increased firing before saccade onset.
  • Both delay and presaccadic activity were modulated by task demands, being higher in the delayed visually guided saccade task.

Conclusions:

  • LIP neurons projecting to the SC convey both visual information and signals related to upcoming saccades.
  • These findings highlight the role of the LIP-SC pathway in integrating visual input with motor preparation for eye movements.