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Short-arm dicentric Y chromosome associated with Sertoli-cell-only tubule
Y Adachi1, I Sasagawa, M Tomaru
1Department of Urology, Yamagata University School of Medicine, Japan.
Scandinavian Journal of Urology and Nephrology
|December 24, 1997
Abstract:
We report a case of a short-arm dicentric Y chromosome associated with Sertoli-cell-only tubule. Chromosomal analysis, using G- and C-banding techniques, revealed: 45,X/46,X psu dic(Y) (pter-->q11::q11-->pter)/46,X + mar. Staining by fluorescence in situ hybridization using a Y chromosome centromere-specific DNA probe showed two bright spots in the pseudodicentric Y chromosome and one in the marker chromosome. It is assumed that Sertoli-cell-only tubule is caused by deletion or disruption of the azoospermic factor gene located distal in Yq11.