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Hyperamylasemia associated with gonococcal salpingitis and perihepatitis

A W Chow, B A Soll, S R Targan

Obstetrics and Gynecology

|July 1, 1976

Summary

Hyperamylasemia can occur with gonococcal salpingitis, mimicking pancreatitis. The amylase to creatinine clearance ratio helps differentiate this condition from pancreatic causes.

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Area of Science:

Reproductive Health
Infectious Diseases
Gastroenterology

Background:

Neisseria gonorrhoeae infections can cause pelvic inflammatory disease, including salpingitis and perihepatitis (Fitzhugh-Curtis syndrome).
Hyperamylasemia, elevated amylase levels in the blood, is often associated with pancreatic diseases but can have other causes.

Observation:

A case study reported hyperamylasemia in a patient with diagnosed gonococcal salpingitis and perihepatitis.
Other common causes of hyperamylasemia, including pancreatic, parotid, biliary, and intestinal diseases, were systematically excluded.

Findings:

The amylase to creatinine clearance ratio was within normal limits.
This ratio suggested a tubal origin for the elevated amylase rather than a pancreatic source.

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Implications:

Elevated amylase levels in gonococcal salpingitis can mimic acute pancreatitis, leading to misdiagnosis.
The amylase to creatinine clearance ratio is a valuable tool for distinguishing hyperamylasemia of tubal origin from pancreatic causes.
Early differentiation is crucial for appropriate management of acute salpingitis, preventing unnecessary surgical interventions.