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Application of lipid microspheres containing prostaglandin E1 ointment to peripheral ischemic ulcers
Y Sakakibara1, T Jikuya, T Mitsui
1Department of Surgery, University of Tsukuba, Japan.
Background:
The systemic use of prostaglandin E1 (PGE1) in the treatment of peripheral vascular disease is well documented. It is known that the liposomal formulation of some drugs enhances their transdermal absorption.
Objective:
The potential of topical application of lipid microspheres containing PGE1 (lipo-PGE1) to treat ischemic ulcers was evaluated.
Methods:
Lipo-PGE1 ointment (1 microgram/g) was applied topically to peripheral ischemic ulcers in 10 patients for 5.8 weeks (range 4-9 weeks). The patients were followed up for 6 months, and response was assessed comparing photographs of the lesions.
Results:
Nine of 10 patients responded to treatment, but in 3 patients, the ulcers recurred after cessation of treatment.
Conclusion:
It is concluded that lipo-PGE1 ointment provides an alternative to the management of patients with incurable peripheral ischemic ulcers.