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Related Experiment Videos

Interstitial brachytherapy for malignant brain tumors

M W McDermott1, P K Sneed, P H Gutin

  • 1Department of Neurological Surgery, University of California, San Francisco 94143-0350, USA. mcdermottm@neuro.ucsf.edu

Seminars in Surgical Oncology
|January 4, 1998
PubMed
Summary
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Interstitial brachytherapy offers improved survival for select brain tumor patients, including glioblastoma and metastases. This review highlights its continued role alongside radiosurgery for challenging cases.

Area of Science:

  • Neurosurgery
  • Radiation Oncology
  • Oncology

Background:

  • Interstitial brachytherapy has been an adjuvant treatment for malignant brain tumors for two decades.
  • Publications suggest improved median survival in carefully selected patients receiving this therapy.

Purpose of the Study:

  • To review the efficacy of interstitial brachytherapy for brain tumors.
  • To focus on results from the University of California, San Francisco, and recent series (post-1990).

Main Methods:

  • Review of clinical trials and standard therapy data.
  • Analysis of published series since 1990, focusing on specific brain tumor types.

Main Results:

  • Interstitial brachytherapy shows benefit for newly diagnosed glioblastoma multiforme, recurrent malignant glioma, brain metastases, and potentially low-grade gliomas.

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  • Iodine-125 (I-125) is the most common radionuclide, with a trend towards permanent low-activity implants over temporary high-activity ones.

    • Conclusions:

    • Interstitial brachytherapy remains a valuable treatment option for malignant brain tumors, even with the advent of radiosurgery.
    • This technique offers a place in managing difficult brain tumor cases.