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Personality genetics

J Benjamin1, R P Ebstein, R H Belmaker

  • 1Laboratory of Clinical Science, National Institute of Mental Heath, Bethesda, MD, USA.

The Israel Journal of Psychiatry and Related Sciences
|January 1, 1997
PubMed
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Researchers identified specific genes influencing personality traits like novelty seeking and reward dependence. This study links the dopamine D4 receptor gene (D4DR) and serotonin 2C receptor gene (5-HT2C) to normal personality variations.

Area of Science:

  • Behavioral genetics
  • Neuroscience
  • Psychiatry

Background:

  • Heritability estimates indicate 30-60% of personality trait variance is genetic.
  • Limited knowledge existed regarding specific genes responsible for normal personality traits.
  • Preliminary studies suggested a quantitative trait locus (QTL) approach for personality genetics.

Purpose of the Study:

  • To investigate the genetic basis of normal personality traits.
  • To identify specific genes associated with personality variations.
  • To explore potential gene-environment interactions in personality.

Main Methods:

  • Conducted independent studies on normal volunteers in Israel (n=124) and the USA (n=315).
  • Employed a quantitative trait locus (QTL) approach.

Related Experiment Videos

  • Analyzed associations between specific genes and personality traits, including the dopamine D4 receptor gene (D4DR) and serotonin 2C receptor gene (5-HT2C).

    • Main Results:

    • Demonstrated a significant association between the dopamine D4 receptor gene (D4DR) and the personality trait of novelty seeking.
    • Identified an interaction between the D4DR gene and the serotonin 2C receptor gene (5-HT2C) affecting reward dependence in the Israeli sample.
    • Found evidence for genetic influence on fundamental personality dimensions.

    Conclusions:

    • The dopamine D4 receptor gene (D4DR) plays a role in novelty seeking.
    • Gene-gene interactions, such as between D4DR and 5-HT2C, influence personality traits like reward dependence.
    • Further research into personality-related genes may illuminate connections between normal personality and psychiatric disorders.