Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Calmodulin point mutations affect Drosophila development and behavior

H B Nelson1, R G Heiman, C Bolduc

  • 1Department of Biochemistry and Cell Biology, Rice University, Houston, Texas 77005-1892, USA.

Genetics
|December 31, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Antimicrobial activity of extracts from macroalgae Ulva lactuca against clinically important Staphylococci is impacted by lunar phase of macroalgae harvest.

Letters in applied microbiology·2016
Same author

A prospective phase III, randomized, double-blind, placebo-controlled study of brodalumab in patients with moderate-to-severe plaque psoriasis.

The British journal of dermatology·2016
Same author

Changes in serum free testosterone, sleep patterns, and 5-alpha-reductase type I activity influence changes in sebum excretion in female subjects.

Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·2014
Same author

A randomized phase 2a efficacy and safety trial of the topical Janus kinase inhibitor tofacitinib in the treatment of chronic plaque psoriasis.

The British journal of dermatology·2013
Same author

Efficacy and safety of topical WBI-1001 in patients with mild to moderate psoriasis: results from a randomized double-blind placebo-controlled, phase II trial.

Journal of the European Academy of Dermatology and Venereology : JEADV·2011
Same author

Treatment of palmoplantar psoriasis with infliximab: a randomized, double-blind placebo-controlled study.

Journal of the European Academy of Dermatology and Venereology : JEADV·2011
Same journal

Inherited long telomeres induce a genome-wide transcriptional response in budding yeast.

Genetics·2026
Same journal

Adaptive Dynamics of Quantitative Traits in a Steadily Changing Environment.

Genetics·2026
Same journal

Functional Landscape of Zebrafish Gonadotropins and Receptors: A Comprehensive Genetic Analysis.

Genetics·2026
Same journal

Synergistic actions of Nup43 and Myosin VI drive actin cone assembly during Drosophila spermiogenesis.

Genetics·2026
Same journal

Identification of two Cryptococcus neoformans heme transporters involved in Fhb1-mediated nitrosative stress protection in a fission yeast model.

Genetics·2026
Same journal

Analysis of a hypomorphic mei-P26 mutation reveals coordination between developmental programming of germ cells and meiotic chromosome dynamics.

Genetics·2026
See all related articles

Calmodulin (CAM) mutations in fruit flies reveal its critical roles in development and behavior. These genetic changes impact head eversion, wing vein formation, and even locomotion, highlighting CAM

Area of Science:

  • Developmental Biology
  • Neuroscience
  • Genetics

Background:

  • Calmodulin (CAM) is a key calcium-binding protein involved in intracellular signaling.
  • Its precise roles in complex developmental and behavioral processes remain largely uncharacterized.

Purpose of the Study:

  • To investigate the function of Calmodulin (CAM) in Drosophila melanogaster development and behavior.
  • To elucidate the effects of specific CAM gene mutations on organismal phenotypes.

Main Methods:

  • Generation and analysis of single amino acid substitution mutations in the endogenous Cam gene.
  • Phenotypic characterization including developmental assays (head eversion, wing venation, cuticle defects) and behavioral tests (climbing, flight).
  • Examination of embryonic phenotypes (chromosome bridging) and structural analysis of CAM mutations.
Keywords:
Non-programmatic

Related Experiment Videos

Main Results:

  • Specific CAM mutations caused pupal lethality due to failed head eversion.
  • Ectopic wing vein formation and melanotic scab formation were observed in various mutant combinations.
  • Maternal effects included anaphase chromosome bridging during early embryonic divisions.
  • Mutants exhibited behavioral deficits such as impaired climbing ability and flightlessness.

Conclusions:

  • Single amino acid changes in Calmodulin significantly disrupt Drosophila development and behavior.
  • These findings implicate Calmodulin in critical processes including morphogenesis, cell division, and neural function.
  • Further research can identify specific CAM targets mediating these diverse effects.