[Immunoenzyme assay for detection of natural antibodies against catecholamines]

Solid-phase enzyme immunoassay (EIA) for detecting natural antibodies to catecholamines (dopamine, adrenaline, and noradrenaline) has been developed. For this purpose catecholamine antigens were synthesized on polymeric matrix. Optimal conditions for EIA detecting antibodies to these antigens in the sera of donors and patients with schizophrenia and disseminated sclerosis were defined. The levels of antibodies to dopamine, adrenaline, and noradrenaline are constant in donors and shifted in the patients.