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Cerebral venous thrombosis and anticardiolipin antibodies

J R Carhuapoma1, P Mitsias, S R Levine

  • 1Department of Neurology, Henry Ford Hospital and Health Sciences Center, Detroit, MI 48202-2689, USA.

Stroke
|December 31, 1997
PubMed

Insights

Anticardiolipin antibodies (aCL) are associated with cerebral venous thrombosis (CVT), particularly in younger women. This condition often involves extensive superficial and deep cerebral venous systems, suggesting aCL is a significant contributing factor to CVT.

Area of Science:

  • Neurology
  • Immunology
  • Vascular Medicine

Background:

  • Cerebral venous thrombosis (CVT) is linked to various pathological states.
  • Isolated reports of CVT associated with anticardiolipin antibodies (aCL) are rare.

Purpose of the Study:

  • To clarify clinical and neuroradiological features of CVT associated with aCL.
  • To determine the outcome of patients with aCL-associated CVT.
  • To systematically review the literature on CVT and aCL.

Main Methods:

  • Retrospective and prospective review of patient records with CVT (1989-1996).
  • Systematic literature review of CVT associated with aCL.
  • Comparison of clinical and neuroradiological features between aCL-positive (aCL+) and aCL-negative (aCL-) CVT patients.

Main Results:

  • Identified 8 aCL+ and 7 aCL- CVT patients; no lupus anticoagulant (LA) patients found.
  • aCL+ CVT patients were younger (mean age 23 vs. 38 years) and more frequently women.
  • Dural sinus involvement was universal in aCL+ patients; deep venous system thrombosis occurred in 63% of aCL+ vs. 14% of aCL- patients.

Conclusions:

  • Anticardiolipin antibodies (aCL) may be a significant factor in CVT development, even with other risk factors present.
  • aCL-associated CVT typically occurs at a younger age.
  • aCL+ CVT shows more extensive superficial and deep cerebral venous system involvement compared to aCL- CVT.
Abstract

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