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Acute colitis associated with etodolac

G M Wilcox1, R S Porensky

  • 1Department of Gastroenterology, Maine Medical Center, Portland, USA.

Journal of Clinical Gastroenterology
|July 1, 1997
PubMed
Summary
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Nonsteroidal anti-inflammatory drug (NSAID) etodolac may cause acute colitis. Symptoms resolved upon drug discontinuation and recurred in one patient upon re-challenge, suggesting a causal link.

Area of Science:

  • Gastroenterology
  • Clinical Pharmacology
  • Drug-Induced Diseases

Background:

  • Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for pain and inflammation.
  • Etodolac is an NSAID commonly prescribed for various conditions.
  • Gastrointestinal side effects are known NSAID complications, but drug-induced colitis is less common.

Observation:

  • Two patients presented with acute colitis during etodolac therapy.
  • Clinical symptoms included abdominal pain, diarrhea, and rectal bleeding.
  • Endoscopic and histopathological findings confirmed active colitis.

Findings:

  • Discontinuation of etodolac led to symptom resolution in both patients.
  • One patient experienced recurrent colitis upon re-administration of etodolac, confirming causality.

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  • The clinical presentation and pathology were indicative of de novo colitis induced by etodolac.

    • Implications:

    • Etodolac should be considered a potential cause of acute colitis.
    • Clinicians should maintain a high index of suspicion for drug-induced colitis in patients on etodolac.
    • Further investigation into the mechanisms of NSAID-induced colitis is warranted.