[The prereplicative period in hepatic regeneration]

Using H3-thymidine autoradiography and biochemical methods, it was revealed that the inhibition of thymidine incorporation in the nuclei of hepatocytes and duodenal crypt epithelial cells occurs in the middle of the preperlicative period (between the liver resection and the increase of DNA synthesis) in the rat regenerating liver. The transition of cells from G1 to phase S was also blocked. No decrease in the uptake of H3-thymidine by liver cells was seen after hepatectomy.