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Omeprazole-induced interstitial nephritis

D Yip1, S Kovac, M Jardine

  • 1Department of Medical Oncology, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia.

Journal of Clinical Gastroenterology
|December 31, 1997
PubMed
Summary
This summary is machine-generated.

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Omeprazole can rarely cause acute kidney injury due to interstitial nephritis. Discontinuation of omeprazole led to full renal function recovery in a patient with ulcerative esophagitis and colon cancer.

Area of Science:

  • Nephrology
  • Gastroenterology
  • Oncology

Background:

  • Proton pump inhibitors like omeprazole are widely used for acid-related gastrointestinal disorders.
  • Acute kidney injury (AKI) is a rare but serious adverse effect associated with omeprazole use.

Observation:

  • A 50-year-old woman developed AKI with interstitial nephritis during omeprazole treatment for ulcerative esophagitis.
  • The patient also underwent chemotherapy for Duke's C colon cancer, but AKI onset correlated with omeprazole use.

Findings:

  • Renal biopsy confirmed interstitial nephritis, a condition characterized by inflammation of the kidney's tubules and surrounding tissues.
  • Serum creatinine levels normalized after omeprazole was discontinued, indicating a causal relationship.

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Implications:

  • This case highlights the importance of considering omeprazole-induced interstitial nephritis in patients presenting with unexplained AKI.
  • Early recognition and withdrawal of omeprazole are crucial for complete renal recovery.