Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cornering and catching the common protein fold

M S Johnson1

  • 1Molecular Modelling and Biocomputing Group, Turku Centre for Biotechnology, Finland. mark.johnson@hops.btk.utu.fi

Molecular Medicine Today
|July 1, 1995
PubMed
Summary

Identifying protein structures from DNA sequences is crucial for drug design. New methods aim to link protein sequences to their 3D folds, even when sequences have diverged significantly.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Why methane surged in the atmosphere during the early 2020s.

Science (New York, N.Y.)·2026
Same author

The <sup>40</sup>Ar(d,p)<sup>41</sup>Ar cross section between 3-7 MeV.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine·2022
Same author

NASA GEOS Composition Forecast Modeling System GEOS-CF v1.0: Stratospheric Composition.

Journal of advances in modeling earth systems·2022
Same author

Interviewing alleged victims with mild and moderate intellectual disabilities and autism: A field study of police-investigated cases of physical and sexual abuse in a Norwegian national sample.

Journal of intellectual disability research : JIDR·2020
Same author

Tracking changes in soil organic carbon across the heterogeneous agricultural landscape of the Lower Fraser Valley of British Columbia.

The Science of the total environment·2020
Same author

ADAPTATION AND RULES OF FORM: CHIRALITY AND SHAPE IN PARTULA SUTURALIS.

Evolution; international journal of organic evolution·2017

Area of Science:

  • Biochemistry
  • Structural Biology
  • Bioinformatics

Background:

  • Protein identification from genomic DNA and cDNA sequences is essential.
  • Protein structure prediction aids drug design and understanding structure-function relationships.

Purpose of the Study:

  • To develop methods linking one-dimensional protein sequences to three-dimensional protein folds.
  • To address the challenge of identifying related proteins with diverged sequences but conserved folds.

Main Methods:

  • Screening of protein coding regions (genomic DNA) and cDNA sequences.
  • Utilizing protein three-dimensional fold identification for structural modeling.
  • Developing computational methods to bridge sequence and structure information.

Main Results:

  • Established a framework for estimating protein structure from sequence data.
  • Demonstrated the feasibility of identifying distantly related proteins based on fold similarity.
  • Highlighted the importance of sequence-to-structure linkage for evolutionary analysis.

Conclusions:

  • Linking protein sequence to fold is key for advancing structural biology and drug discovery.
  • Computational modeling can overcome sequence divergence to identify evolutionary relationships.
  • This approach enhances the ability to analyze protein families and functions.

Related Experiment Videos