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Chronic renal failure in India

S Mittal1, V Kher, S Gulati

  • 1Department of Nephrology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Uttar Pradesh, India.

Renal Failure
|January 7, 1998
PubMed
Summary
This summary is machine-generated.

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This study on chronic renal failure (CRF) in India found glomerulonephritis and diabetic nephropathy as leading causes. Poorer prognosis is linked to late referrals and limited renal replacement therapy access.

Area of Science:

  • Nephrology
  • Epidemiology
  • Internal Medicine

Background:

  • Chronic renal failure (CRF) is a significant global health concern.
  • Understanding the etiologies and outcomes of CRF is crucial for public health initiatives.

Purpose of the Study:

  • To prospectively investigate the causes, clinical features, and outcomes of chronic renal failure (CRF) in India.
  • To compare the pattern of CRF in India with that in developed countries.

Main Methods:

  • Prospective study of 835 new chronic renal failure (CRF) cases over one year.
  • Diagnosis based on clinical, laboratory, and radiological features; kidney biopsies performed when indicated.
  • Patients categorized into etiologic groups; outcomes assessed at one year.

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Main Results:

  • Glomerulonephritis (28.6%) and diabetic nephropathy (23.2%) were the most common causes of CRF.
  • Diabetic nephropathy was the leading cause in patients over 40 (36.8%).
  • Outcomes at one year included death (12.5% of end-stage renal disease patients), kidney transplantation (17%), and dialysis (12.7%), with significant loss to follow-up.

Conclusions:

  • The pattern of CRF in India resembles developed countries, but prognosis is poorer.
  • Late referral and limited access to renal replacement therapy contribute to worse outcomes in India.