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Functional brain imaging and aging in schizophrenia

M S Buchsbaum1, E A Hazlett

  • 1Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029-6574, USA. mbuchsba@petlab.mssm.edu

Schizophrenia Research
|January 7, 1998
PubMed
Summary
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Schizophrenia patients exhibit brain changes similar to normal aging, like enlarged ventricles and reduced frontal activity. This suggests premature aging processes may affect the brain in schizophrenia.

Area of Science:

  • Neuroimaging
  • Schizophrenia Research
  • Brain Aging

Background:

  • Schizophrenia shares brain imaging similarities with normal aging, including ventricular enlargement and reduced frontal cortical activity.
  • These similarities suggest premature brain aging processes in some schizophrenia patients.
  • Atypical changes in basal ganglia may occur in schizophrenia, potentially due to neuroleptic treatment.

Purpose of the Study:

  • To explore the relationship between brain changes in schizophrenia and normal aging processes.
  • To investigate potential progressive brain changes in schizophrenia analogous to aging.
  • To examine regional brain alterations, specifically in the basal ganglia, in schizophrenia.

Main Methods:

  • Utilized brain imaging techniques to compare patients with schizophrenia to normal controls.

Related Experiment Videos

  • Analyzed volumetric and metabolic changes in various brain regions.
  • Considered the influence of illness duration and neuroleptic treatment.

    • Main Results:

    • Patients with schizophrenia show ventricular enlargement and diminished frontal cortical activity, mirroring findings in older normal controls.
    • The basal ganglia may exhibit unique volumetric and metabolic changes in schizophrenia.
    • Age and illness duration were found to be highly correlated in the study samples.

    Conclusions:

    • Brain imaging findings in schizophrenia suggest parallels with normal aging, potentially indicating premature or accelerated aging processes.
    • The basal ganglia present a distinct pattern of change in schizophrenia, possibly influenced by medication.
    • Further research with larger cohorts of early-stage patients and longitudinal designs is needed to clarify these findings.