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[Therapeutic thrombocytapheresis--effect on hemorheologic parameters]
R Langer1, D Gross, B Mansouri Taleghani
1Abteilung Experimentelle Chirurgie, Chirurgische Universitätsklinik, Würzburg, Deutschland.
Beitrage Zur Infusionstherapie Und Transfusionsmedizin = Contributions to Infusion Therapy and Transfusion Medicine
|January 1, 1997
Summary
Platelet pheresis (mTD) effectively alleviates myeloproliferative disease symptoms by improving blood flow. This treatment normalizes plasma viscosity and reduces erythrocyte aggregation, easing neurological discomfort.
Area of Science:
- Hematology
- Neurology
- Rheology
Context:
- Myeloproliferative diseases (CMPE) are characterized by high platelet counts and debilitating subjective symptoms.
- Platelet pheresis (mTD) is a treatment that reduces platelet levels and improves patient well-being.
Purpose:
- To investigate the role of rheological mechanisms in CMPE symptom relief following platelet pheresis.
- To analyze blood rheological parameters before and after mTD in CMPE patients.
Summary:
- While whole blood viscosity and erythrocyte filterability remained unchanged, mTD normalized moderately elevated plasma viscosity in CMPE patients.
- A significant reduction in erythrocyte aggregation was observed post-mTD treatment.
- No significant differences in rheological parameters were found between patients and controls before treatment.
Impact:
- Hemorheological factors significantly influence subjective symptoms in CMPE patients.
- Reduced erythrocyte aggregation improves microcirculatory fluidity, potentially alleviating neurological symptoms.
- Findings suggest neurological dysfunction due to restricted cortical microcirculation is linked to CMPE symptoms.