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[Selenium substitution in acute myocardial infarct]
1Funktionsbereich Internistische Intensivtherapie, Klinik für Innere Medizin III, Jena.
Medizinische Klinik (Munich, Germany : 1983)
|January 7, 1998
Summary
Selenium supplementation may reduce complications in acute myocardial infarction patients with low selenium levels. This study found fewer instances of left heart failure in patients receiving selenium therapy.
Area of Science:
- Cardiology
- Nutritional Science
- Biochemistry
Background:
- Previous research indicates lower selenium levels in patients experiencing myocardial infarction.
- Selenium is a crucial trace element involved in antioxidant defense mechanisms.
Purpose of the Study:
- To investigate the impact of selenium supplementation on patients with acute myocardial infarction.
- To assess selenium levels and clinical outcomes in myocardial infarction patients receiving selenium therapy.
Main Methods:
- A study involving 28 patients with myocardial infarction receiving selenium treatment alongside standard care.
- A control group of 19 myocardial infarction patients received only standard care.
- Measurements included serum, whole blood, and urine selenium levels, along with documented myocardial infarction complications.
Main Results:
- Intravenous selenium therapy significantly increased serum and whole blood selenium and glutathione peroxidase levels during the acute phase (days 1-3).
- The selenium group experienced less left heart failure (20%) compared to the control group (57%).
- While both groups saw a reduction in tachycardial rhythm disturbances, ventricular extrasystoles specifically decreased in the selenium group.
Conclusions:
- Selenium substitution is recommended for acute myocardial infarction patients with documented low selenium levels.
- Further investigation through a prospective, double-blind study is warranted to confirm these findings.