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Riboflavin deficiency in infants and children with heart disease

M Steier, R Lopez, J M Cooperman

    American Heart Journal
    |August 1, 1976
    PubMed

    Insights

    Children with cardiac disease show a higher prevalence of riboflavin deficiency compared to healthy peers. This highlights potential nutritional risks in pediatric heart patients.

    Area of Science:

    • Pediatric Cardiology
    • Nutritional Biochemistry
    • Public Health

    Background:

    • Riboflavin (vitamin B2) deficiency can impact overall health.
    • Assessing nutritional status is crucial in vulnerable pediatric populations.
    • Cardiac conditions may influence nutrient metabolism and requirements.

    Purpose of the Study:

    • To determine the prevalence of riboflavin deficiency in infants and children with cardiac disease.
    • To compare this prevalence against a control group of similar socioeconomic status.
    • To investigate the association between cardiac disease severity and riboflavin status.

    Main Methods:

    • Randomized selection of 31 infants and children with cardiac disease.
    • Utilized erythrocyte glutathione reductase activity (EGRAC) to assess riboflavin status.
    • Compared findings with a control group of comparable socioeconomic status.

    Main Results:

    • Eleven out of 31 children with cardiac disease exhibited riboflavin deficiency.
    • This prevalence was significantly higher than in the control group.
    • Deficiency was observed in both congenital and acquired heart disease, with a trend towards higher rates in congestive heart failure.

    Conclusions:

    • Riboflavin deficiency is more prevalent in pediatric patients with cardiac disease.
    • Nutritional deficiencies may be underestimated in children with heart conditions.
    • Screening for vitamin deficiencies should be considered in this patient group.

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