Related Experiment Videos
Minimal requirement for a lentivirus vector based on human immunodeficiency virus type 1
V N Kim1, K Mitrophanous, S M Kingsman
1Biochemistry Department, Oxford University, United Kingdom.
Journal of Virology
|January 7, 1998
Abstract:
The use of human immunodeficiency virus vectors for gene therapy is hampered by concern over their safety. This concern might be ameliorated, in part, if the viral accessory genes and proteins could be eliminated from the vector genomes and particles. Here we describe a minimal vector system that is capable of transducing nondividing cells and which does not contain tat, vif, vpr, vpu, and nef.