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Relation between leucocyte depletion and storage

V Weisbach1, M Riewald, J Zingsem

  • 1Abteilung für Transfusionsmedizin, Chirurgische Klinik, FAU Erlangen-Nürnberg.

Beitrage Zur Infusionstherapie Und Transfusionsmedizin = Contributions to Infusion Therapy and Transfusion Medicine
|January 1, 1994
PubMed
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Filtration effectively removes leukocytes from platelet concentrates regardless of storage time. Pre-storage filtration does not significantly improve the quality of platelet concentrates after 5 days if initial leukocyte contamination is low.

Area of Science:

  • Transfusion Medicine
  • Hematology
  • Biomedical Engineering

Background:

  • Platelet concentrates (PCs) are crucial for treating thrombocytopenia.
  • Leukocyte contamination in PCs can lead to adverse transfusion reactions.
  • Filtration is a common method for reducing leukocyte content in PCs.

Purpose of the Study:

  • To determine if storage time affects the efficacy of leukocyte depletion in PCs by filtration.
  • To evaluate if pre-storage filtration improves the post-storage quality of PCs.

Main Methods:

  • Parallel testing of 10 double-sized PCs, with halves filtered pre-storage and post-storage (5 days).
  • Utilized a polyester filter (PL 50, Pall) for leukocyte depletion.
  • Assessed efficacy of leukocyte depletion and post-storage quality parameters.

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Main Results:

  • Leukocyte depletion efficacy was independent of the storage age of PCs.
  • Pre-storage filtration did not enhance the quality of 5-day stored PCs.
  • This finding held true when initial leukocyte contamination was below 0.5 x 10^8/unit.

Conclusions:

  • The timing of leukocyte filtration (pre- vs. post-storage) does not impact its efficacy.
  • Pre-storage filtration offers no significant advantage for improving the quality of short-term stored PCs.
  • Current filtration methods are effective regardless of PC storage duration, provided initial contamination is controlled.