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Are single-needle protocols equivalent to dual-needle protocols for platelet apheresis?
J Zingsem1, V Weisbach, T Zeiler
1Abteilung für Transfusionsmedizin, Friedrich-Alexander-Universität Erlangen, Germany.
Beitrage Zur Infusionstherapie Und Transfusionsmedizin = Contributions to Infusion Therapy and Transfusion Medicine
|January 1, 1994
Summary
One-needle thrombocytapheresis is as effective as two-needle methods for platelet yield and donor safety when programs are optimized. This technique addresses donor venous issues and increasing demands in cytapheresis.
Area of Science:
- Hematology
- Apheresis Technology
Background:
- Increasing demands on cytapheresis donors necessitate alternative procedures.
- Donor venous complications are a concern with current apheresis techniques.
Purpose of the Study:
- To compare the efficacy of one-needle and two-needle thrombocytapheresis techniques.
- To evaluate platelet yield and product quality across different cell separators.
Main Methods:
- Comparison of five one-needle and three two-needle apheresis programs.
- Utilized four different cell separators for evaluation.
- Leukopenia assessed using Nageotte chamber counting.
Main Results:
- One-needle thrombocytapheresis achieved equivalent platelet yields compared to two-needle techniques.
- Leukopenia in products was comparable between one-needle and two-needle methods.
- Effectiveness is dependent on suitable program adjustment for the one-needle technique.
Conclusions:
- Optimized one-needle thrombocytapheresis offers a viable alternative to two-needle methods.
- This technique can help mitigate donor venous issues and meet increased apheresis demands.
- Program adjustment is crucial for successful implementation of one-needle apheresis.