Atraumatic cardiac arrest in apparently healthy young women

Sudden non-traumatic death in young people (< 30 years old) has been discussed both in systematic studies and anecdotal reports. After presenting three remarkable cases, a global survey of the incidence with special reference to the Belgian CPCR database, ethiopathogenesis and prognosis of sudden non-traumatic death in this specific age group is given. The atherosclerotic coronary artery disease (CAD) related and especially the non-CAD related causes are extensively discussed as well as the role of intoxication and increasing drug and substance abuse. After conventional cardiopulmonary resuscitation with restoration of spontaneous circulation and a favourable neurological outcome, a thorough search for the underlying disease is mandatory. The involvement of drugs or other toxins has to be excluded in the first place. Apart from transoesophageal echocardiography and coronary angiography, electrophysiological testing, serological exams, myocardial biopsy and magnetic resonance imaging should be considered.