Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Defect of platelet function associated with chronic hypoglycaemia

R A Hutton, A J Macnab, R P Rivers

    Archives of Disease in Childhood
    |January 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Celebrity endorsed music videos: innovation to foster youth health promotion.

    Health promotion international·2018
    Same author

    A Note on Some Cases of Poisoning by Scopolia Lurida,-Atropaceæ: Proceedings of the Peshawar Medical Society.

    The Indian medical gazette·2017
    Same author

    Two Cases of Compound Depressed Fracture of the Skull-Recovery.

    The Indian medical gazette·2017
    Same author

    The Famous Marches of the Guides.

    The Indian medical gazette·2017
    Same author

    Priorities for African youth for engaging in DOHaD.

    Journal of developmental origins of health and disease·2017
    Same author

    Traumatic spinal cord injury in Uganda: a prevention strategy and mechanism to improve home care.

    International journal of epidemiology·2017
    Same journal

    Protecting adolescent confidentiality in the digital age: a global call for adolescent-informed electronic health records.

    Archives of disease in childhood·2026
    Same journal

    Diagnostic accuracy study assessing the ability of paediatric asthma scores to predict admission following initial emergency department bronchodilator therapy: a Clinical Asthma Scoring systems in Paediatric Emergency (CASPER) study.

    Archives of disease in childhood·2026
    Same journal

    Artificial intelligence for child health: current capabilities and the next frontier.

    Archives of disease in childhood·2026
    Same journal

    Troubled origins and lasting impact of the first insulin injection.

    Archives of disease in childhood·2026
    Same journal

    Paediatric readiness assessment tools in emergency care: a scoping review.

    Archives of disease in childhood·2026
    Same journal

    Building a paediatric workforce to deliver the NHS prevention agenda: time for paediatric public health medicine?

    Archives of disease in childhood·2026
    See all related articles

    Patients with glycogen storage diseases experienced bleeding issues due to platelet dysfunction. Stabilizing blood glucose levels rapidly corrected these platelet abnormalities, improving function.

    Area of Science:

    • Biochemistry
    • Hematology
    • Pediatric Endocrinology

    Background:

    • Chronic hypoglycemia in glycogen storage diseases (GSDs) can lead to severe complications.
    • Platelet dysfunction, including impaired aggregation and adenine nucleotide deficiency, has been observed in GSDs.

    Observation:

    • Two patients with GSDs (Type I and fructose-1,6-diphosphatase deficiency) presented with bleeding diathesis.
    • These patients exhibited defective platelet aggregation and reduced platelet adenine nucleotides.

    Findings:

    • Normalization of blood glucose levels rapidly corrected the platelet aggregation defects and restored adenine nucleotide levels.
    • Improved platelet function persisted throughout the period of normoglycemia.

    Implications:

    Related Experiment Videos

    • Maintaining normoglycemia is crucial for managing bleeding risks in patients with these GSDs.
    • Correction of platelet abnormalities facilitates necessary medical procedures like liver biopsy and surgery.