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Endothelial function, fibrinolysis, and angiotensin-converting enzyme inhibition
1Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA.
Clinical Cardiology
|January 10, 1998
Abstract:
Experimental and clinical studies with angiotensin-converting enzyme (ACE) inhibitors have suggested that these agents may reduce the risk of atherothrombotic events. Recent studies have identified the role of angiotensin II and ACE in the regulation of fibrinolysis. There is now substantial evidence that the renin-angiotensin system (RAS) plays an important role in the regulation of vascular fibrinolytic balance. This recently recognized relationship may contribute to the vasculoprotective effects of ACE inhibitors.