Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Mivacurium]

J R Ortiz1, F Carrascosa

  • 1Servicio de Anestesiología y Reanimación, Facultad de Medicina, Universidad de Navarra.

Revista Espanola De Anestesiologia Y Reanimacion
|January 10, 1998
PubMed
Summary

Mivacurium, a short-acting nondepolarizing muscle relaxant, offers rapid reversal and is suitable for procedures of unpredictable duration. Careful monitoring is advised due to potential histamine release and prolonged effects in patients with low cholinesterase activity.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The power of registry studies to inform maternal influenza vaccine policy and practice.

Journal of internal medicine·2019
Same author

Maternal influenza and birth outcomes: systematic review of comparative studies.

BJOG : an international journal of obstetrics and gynaecology·2016
Same author

Reply to 'What to do if the endotracheal tube will not pass through the nasal passage during fiberoptic nasotracheal intubation'.

Acta anaesthesiologica Scandinavica·2008
Same author

Comparative study of intubating conditions at the first minute with suxamethonium, rocuronium and different priming techniques of rocuronium.

European journal of anaesthesiology·2005
Same author

Cost-effectiveness of three combinations of antiemetics in the prevention of postoperative nausea and vomiting.

British journal of anaesthesia·2003
Same author

A comparison of three antiemetic combinations for the prevention of postoperative nausea and vomiting.

Anesthesia and analgesia·2002

Area of Science:

  • Anesthesiology
  • Pharmacology

Background:

  • Mivacurium is a short-acting nondepolarizing muscle relaxant (NDPMR) with a benzyl-isoquinoline structure.
  • Its rapid, spontaneous reversal is attributed to hydrolysis by plasma cholinesterase.
  • The drug's structure can promote histamine release, potentially causing adverse reactions.

Purpose of the Study:

  • To evaluate the efficacy and safety of mivacurium as a muscle relaxant.
  • To characterize the dose-dependency and reversal times of mivacurium in adults and children.
  • To identify patient populations at risk for prolonged neuromuscular blockade.

Main Methods:

  • Review of mivacurium's pharmacokinetic and pharmacodynamic properties.
  • Analysis of clinical data regarding duration of action and reversal times.
  • Identification of factors influencing mivacurium's metabolism and effects.

Main Results:

  • Mivacurium provides effective neuromuscular blockade with rapid spontaneous reversal.
  • Duration of action and reversal are less dose-dependent compared to intermediate-acting NDPMRs.
  • In children, mivacurium has a shorter duration and faster reversal than in adults.
  • Prolonged blockade may occur in patients with reduced plasma cholinesterase activity.

Conclusions:

  • Mivacurium is indicated for short or unpredictable procedures requiring rapid reversal, especially when avoiding anticholinesterase agents.
  • Monitoring is recommended, particularly in patients with potential cholinesterase deficiency.
  • Its rapid reversal profile makes it a valuable option in specific anesthetic scenarios.

Related Experiment Videos