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12:19
Analysis of Cell Cycle Position in Mammalian Cells
Published on: January 21, 2012
Controlling cell proliferation in differentiating tissues: genetic analysis of negative regulators of G1-->S-phase
1Department of Biological Chemistry, School of Medicine, University of California at Los Angeles 90095, USA. zavitz@hhmi.ucla.edu
Current Opinion in Cell Biology
|January 13, 1998
Abstract:
Withdrawal from the cell cycle as cells begin to differentiate is accomplished by the downregulation of cyclin-dependent kinase activities in G1 phase. Recent analysis of loss-of-function mutations in flies, worms, and mice has provided insight into the roles of various negative regulators of G1 phase in developing organisms.
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