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Ocular motor abnormalities in Huntington's disease

A G Lasker1, D S Zee

  • 1Department of Neurology, Johns Hopkins Hospital, Baltimore, MD 21267, USA.

Vision Research
|January 13, 1998
PubMed
Summary

Huntington

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Area of Science:

  • Neuroscience
  • Ophthalmology
  • Neurology

Background:

  • Huntington's disease (HD) is a neurodegenerative disorder.
  • Eye movement abnormalities, particularly saccades, are characteristic of HD.

Purpose of the Study:

  • To review eye movement abnormalities in Huntington's disease patients.
  • To focus on saccadic eye movements as key indicators of HD progression.

Main Methods:

  • Review of existing literature on eye movements in Huntington's disease.
  • Analysis of saccadic abnormalities, including reflexive and voluntary saccades.

Main Results:

  • Early and consistent findings include impaired suppression of reflexive saccades and delayed voluntary saccades.
  • Saccadic slowing is observed, particularly in early-onset HD, suggesting involvement of higher-level and brainstem centers.
  • These findings support models implicating the frontal lobes and basal ganglia in saccade control.

Conclusions:

  • Eye movement studies in HD provide insights into higher-level control deficits.
  • Saccadic abnormalities serve as a paradigm for studying neurological diseases affecting eye movements.

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