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Is CTLA-4 a negative regulator for T-cell activation?
1Michael Heidelberger Division of Immunology, Dept of Pathology, New York University Medical Center, NY 10016, USA. liuy01@mcrcr6.med.nyu.edu
Immunology Today
|January 13, 1998
Abstract:
Immune responses can be a two-sided sword: although lack of immunity can be fatal, so can over-activation of the immune system. The concept of homeostatic balance in immune regulation has consequently been at the core of immune research. In this context, Yang Liu takes a cautious view of the concept that CTLA-4 is a negative regulator of T-cell activation.