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Regulatory feedback pathways in the thymus
R Mehr1, A S Perelson, M Fridkis-Hareli
1Dept of Molecular Biology, Princeton University, NJ 08544, USA. ramit@princeton.edu
Immunology Today
|January 13, 1998
Abstract:
The idea that thymocytopoiesis may be subject to feedback regulation by mature lymphocytes is proposed on the basis of recent data from in vitro experimental models. Analysis of the data using mathematical models, presented here by Ramit Mehr and colleagues, suggests possible feedback control mechanisms in T-cell development.