Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Lipoprotein changes in children after liver transplantation: mild hypertriglyceridemia and a decrease in HDL3/HDL2

¹Department of Pediatrics, Hadassah University Hospital, Jerusalem, Israel.

Hepatology (Baltimore, Md.)

|January 13, 1998

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Prenatal diagnosis of biliary atresia: A case series.

Early human development·2017

Same author

Yersinia enterocolitica Infection Simulating Lymphoproliferative Disease, after Liver Transplant.

Case reports in transplantation·2014

Same author

Living related liver transplant following bone marrow transplantation from same donor: long-term survival without immunosuppression.

Pediatric transplantation·2010

Same author

Subwavelength spatial solitons.

Optics letters·2008

Same author

Enhanced photoinduced chi((2)) in gamma-ray-irradiated bulk glass.

Optics letters·2007

Same author

Afebrile seizures and rotavirus gastroenteritis: an infrequently recognized association.

Clinical pediatrics·2007

Same journal

Decoding fibrosis: Transcriptomic and clinical insights via AI-derived collagen deposition phenotypes in MASLD.

Hepatology (Baltimore, Md.)·2026

Same journal

A randomized controlled trial of stepped treatment to reduce unhealthy alcohol use in patients with chronic liver disease.

Hepatology (Baltimore, Md.)·2026

Same journal

AASLD AST NASPGHAN Practice Guideline on pediatric liver transplantation: Candidate evaluation.

Hepatology (Baltimore, Md.)·2026

Same journal

H4K12 lactylation drives TREM2high macrophages differentiation in liver fibrosis.

Hepatology (Baltimore, Md.)·2026

Same journal

Good vibrations: Using VCTE to predict hepatic decompensation in MASLD.

Hepatology (Baltimore, Md.)·2026

Same journal

One size does not fit all: Global variability in noninvasive testing for MASLD.

Hepatology (Baltimore, Md.)·2026

See all related articles

Children after liver transplantation show mild hypertriglyceridemia and an increased HDL2 to HDL3 ratio, potentially offering cardiovascular protection. Further research is needed to confirm these findings in pediatric transplant patients.

Area of Science:

Pediatric transplantation
Lipid metabolism
Cardiovascular health

Background:

Hyperlipidemia is common post-organ transplant, impacting long-term outcomes.
Pediatric data on post-transplant dyslipidemia is inconsistent.
Liver transplantation in children requires understanding lipid profile changes.

Purpose of the Study:

To characterize the lipoprotein profile in children post-liver transplantation.
To compare lipid profiles with healthy siblings and population controls.
To assess the clinical relevance of observed lipoprotein alterations.

Main Methods:

Analyzed plasma triglyceride and cholesterol levels in 10 pediatric liver transplant recipients.
Isolated and analyzed lipoprotein fractions (VLDL, LDL, HDL2, HDL3) for chemical composition.

Related Experiment Videos

Compared lipid profiles and lipoprotein particle composition with control groups.

Main Results:

Elevated plasma triglyceride and VLDL cholesterol levels were observed post-transplantation.
No significant differences in LDL-C or total HDL-C levels compared to controls.
Increased HDL2 relative to HDL3 subfractions, without altered cholesteryl ester transfer protein activity.

Conclusions:

Children post-liver transplantation exhibit mild hypertriglyceridemia and a shift towards HDL2.
The increase in HDL2, a potentially atheroprotective particle, may have clinical significance.
These findings warrant further investigation into the long-term cardiovascular implications in pediatric transplant patients.