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A role for inflammatory cytokines in the productive activation of antigen-specific CD4+ T-cells

K A Pape1, M K Jenkins

  • 1Department of Microbiology, University of Minnesota Medical School, Minneapolis 55455, USA.

Agents and Actions. Supplements
|January 14, 1998
PubMed

The mechanisms of action of immunological adjuvants were studied using a system in which the behavior of adoptively transferred CD4+ T-cell receptor transgenic T-cells could be directly monitored following antigen administration. These studies revealed that adjuvant-induced inflammatory cytokines promote immunity by enhancing the clonal expansion, persistence and differentiation of antigen-activated CD4+ T-cells.

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