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Updated: Sep 10, 2026

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Published on: July 19, 2018
Beta 2-microglobulin amyloidosis presenting as esophageal perforation in a hemodialysis patient
G A Khan1, F I Lewis, M Dasgupta
1Woods Memorial Hospital, Etowah, Tenn. 37331, USA.
Abstract:
A 45-year-old male with hypertensive end-stage renal disease and on maintenance hemodialysis for 13 years is reported. He presented with life-threatening hematemesis, secondary to esophageal rupture. Immunohistological staining and electron microscopy examination of the esophageal perforation showed depositions of beta 2-microglobulin (beta 2-M) amyoloid. The unique aspect presented here is the localized esophageal involvement with beta 2-M amyloidosis. This is the first reported patient with esophageal perforation, due to the deposition and infiltration of the lower esophagus with beta 2-M which predisposed to its rupture.
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