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Tumor angiogenesis as a major prognostic factor in stage I lung adenocarcinoma
T Kawaguchi1, S Yamamoto, S Kudoh
1Department of Internal Medicine, National Kinki Central Hospital, Osaka, Japan.
Unlabelled:
We investigated the correlation between tumor angiogenesis and prognosis of T1N0M0 lung adenocarcinoma.
Materials And Methods:
Forty two specimens resected from patients with T1NOM0 lung adenocarcinoma were investigated by immunohistochemical staining with a monoclonal antibody to CD31. The relationship between microvessel count, clinicopathologic factors and prognosis was studied.
Results:
The microvessel count was significantly higher in cases with vessel invasions than in those without. Univariate analysis showed that microvessel count was related to poorer prognosis. In patients with a high microvessel count (> or = 38), prognosis was significantly poorer than in those with a low count (< 38). Multivariate analysis indicated that the microvessel count and mitosis are prognostic factors in patients with lung cancer, and that the microvessel count is a more important factor than mitosis.
Conclusions:
Microvessel count may be a major prognostic factor and a useful tool to predict recurrence in patients with T1N0M0 lung adenocarcinoma.