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Related Experiment Videos

Midterm reversible failure in trabeculectomies with adjunctive mitomycin-C

N Kasahara1, T J Smith, S A Sibayan

  • 1New England Glaucoma Research Foundation, Schepens Eye Research Institute.

Ophthalmic Surgery and Lasers
|January 15, 1998
PubMed
Summary

Midterm failure of trabeculectomy with mitomycin-C (MMC) can occur but is often reversible. Laser suture lysis (LSL) effectively reduced intraocular pressure (IOP) in most cases without complications.

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Area of Science:

  • Ophthalmology
  • Glaucoma Surgery
  • Surgical Outcomes

Background:

  • Trabeculectomy is a common glaucoma surgery.
  • Failure can occur early or late, but midterm failure is less common.
  • Antifibrotic agents like mitomycin-C (MMC) are used to improve success rates.

Purpose of the Study:

  • To determine the incidence of midterm failure in trabeculectomy with MMC.
  • To evaluate the safety and efficacy of laser suture lysis (LSL) in reversing midterm failure.

Main Methods:

  • Retrospective review of 130 patients undergoing trabeculectomy with MMC.
  • Analysis of cases with increased intraocular pressure (IOP) between 21 and 185 days post-surgery.

Main Results:

Related Experiment Videos

  • 14 patients (15 eyes) experienced midterm failure (median 41 days).
  • Laser suture lysis (LSL) successfully lowered IOP in 66.6% of affected eyes.
  • No complications were associated with LSL procedures.

    • Conclusions:

    • Midterm failure of trabeculectomy with MMC is reversible.
    • LSL is a safe and effective option for managing midterm failure.
    • The reversibility of midterm failure may be specific to MMC use.