Related Experiment Videos
Perphenazine decreases vomiting by children after tonsillectomy
1Department of Anaesthesia, Children's Hospital of Eastern Ontario, Ottawa, Canada. Splinter@cheo.on.ca
Canadian Journal of Anaesthesia = Journal Canadien D'Anesthesie
|January 16, 1998
Summary
Perphenazine effectively reduces post-tonsillectomy vomiting in children. This study found fewer vomiting episodes and less need for rescue antiemetics in children receiving perphenazine compared to placebo.
Area of Science:
- Pediatric Anesthesiology
- Pharmacology
- Surgical Outcomes
Background:
- Post-tonsillectomy nausea and vomiting (PONV) is a common complication in pediatric patients.
- Effective antiemetic prophylaxis is crucial for improving patient recovery and reducing hospital stay.
Purpose of the Study:
- To evaluate the efficacy of perphenazine in preventing vomiting in children following tonsillectomy.
- To test the hypothesis that perphenazine administration decreases the incidence of post-tonsillectomy emesis.
Main Methods:
- A randomized, double-blind, placebo-controlled trial involving 260 children aged 2-12 years undergoing tonsillectomy.
- Participants received either intravenous perphenazine (70 µg/kg, max 5 mg) or placebo before surgery.
- Standardized management of fluids, emesis, and pain was implemented.
Main Results:
- Perphenazine significantly reduced vomiting incidence within 24 hours post-surgery (42% vs. 57% in placebo group, P < 0.01).
- Fewer rescue antiemetics were required in the perphenazine group (P < 0.05).
- Each vomiting episode delayed hospital discharge by approximately 20 minutes.
Conclusions:
- Prophylactic perphenazine is effective in decreasing vomiting in children after tonsillectomy.
- Perphenazine improves outcomes by reducing emesis and potentially shortening hospital stays.