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Levonorgestrel subdermal implants. Contraception on trial

M L Frank1, C DiMaria

  • 1University of New Haven, West Haven, Connecticut, USA. MLFrank@Charger.NewHaven.edu

Drug Safety
|January 16, 1998
PubMed
Summary

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This summary is machine-generated.

Levonorgestrel subdermal implants offer effective, long-acting contraception but face controversy due to adverse effects and legal issues. This controversy may hinder future contraceptive development, impacting women

Area of Science:

  • Reproductive Health
  • Contraceptive Technology
  • Pharmacovigilance

Background:

  • Levonorgestrel subdermal implants emerged in the 1980s as a highly effective, long-acting hormonal contraceptive option.
  • These implants offer user compliance advantages over traditional methods.
  • Despite initial broad acceptability, implants now face significant opposition.

Purpose of the Study:

  • To examine the controversies surrounding levonorgestrel subdermal implants.
  • To assess the impact of these controversies on future contraceptive development.

Main Methods:

  • Review of reported adverse effects associated with levonorgestrel implants.
  • Analysis of legal challenges and media attention concerning implant safety and use.
  • Evaluation of trends in contraceptive research and development funding and incentives.
Keywords:
AmericasContraceptionContraception ResearchContraceptive Agents, Female--legal aspectsContraceptive Agents, Female--side effectsContraceptive Agents, Progestin--legal aspectsContraceptive Agents, Progestin--side effectsContraceptive Agents--legal aspectsContraceptive Agents--side effectsContraceptive EffectivenessContraceptive Implants--historyContraceptive Implants--legal aspectsContraceptive Implants--side effectsContraceptive Methods--historyContraceptive Methods--legal aspectsContraceptive Methods--side effectsContraceptive UsageDeveloped CountriesFamily PlanningFamily Planning PolicyInvoluntary Fertility ControlLevonorgestrel--legal aspectsLevonorgestrel--side effectsLiterature ReviewMethod AcceptabilityNorth AmericaNorthern AmericaPolicyPopulation PolicySocial PolicyUnited States

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Main Results:

  • Reported adverse effects and problematic implant removals have led to opposition.
  • Concerns regarding potential coercive use and numerous lawsuits have generated negative publicity.
  • The implant controversy exacerbates a pre-existing decline in contraceptive development.

Conclusions:

  • The experience with levonorgestrel subdermal implants has created significant disincentives for further contraceptive research and development.
  • Litigation and controversy surrounding these implants may accelerate the decline in new contraceptive method innovation.